Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

Roderic John R. Magtulis, Emvie Loyd P. Itable, RN, MAN

Abstract

Objective: Diabetes Mellitus is a leading illness to the society and despite of a lot of researches, not a single cure has been discovered. Most of the time, people focused on fighting diabetes and medicinal plants were utilized. The purpose of this study was to investigate the hypoglycemic effect of Scarlet Spiral Flag (Costus woodsonii) and to be reviewed for preclinical trials.

Methods: 20 male Swiss mice were made diabetic by inducing Alloxan monohydrate. Then separated randomly into 4 groups with different treatments administered daily for 7 days; Control, Positive Control (600 µg/kg Glibenclamide), T1 (250mg/kg Scarlet Spiral Flag ethanolic extract) and T2 (500mg/kg Scarlet Spiral Flag ethanolic extract). Their blood sugar was monitored onset after 1st treatment (6th, 12th and 24th hours) and during the week within the 1st, 4th and 8th day.

Results: Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice.

Conclusion: The ethanolic extract of Scarlet Spiral Flag (Costus woodsonii) has a potent antidiabetic effect in Alloxan-induced diabetic mice. Since it is under the same Genus of the Insulin plant, it has a common effect in terms of lowering the blood glucose level.

Keywords: Acclimatization, Alloxan, Costus woodsonii, Ethanolic Extract, Oral Gavage

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